一對一理科課題：了解Mac-1（CD11b/CD18）是一種寡核苷酸結合蛋白

課題內(nei) 容

該教授研究了磷酸二酯和硫代磷酸酯寡核苷酸與(yu) Mac-1（CD11b/CD18；αMβ2）的相互作用，Mac-1是一種肝素結合的整合素，主要存在於(yu) 多形核白細胞（PMNs）、巨噬細胞和自然殺傷(shang) 細胞的表麵。在αM和β2亞(ya) 基上都發生了胸苷的均聚物的結合。可溶性纖維蛋白原是Mac-1的天然配體(ti) ，是硫代磷酸酯寡核苷酸與(yu) TNF-α激活的和未激活的PMNs結合的優(you) 秀競爭(zheng) 者。

細胞表麵Mac-1表達的上調增加了寡脫氧核苷酸的細胞表麵結合。結合被抗Mac-1單克隆抗體(ti) 所抑製，細胞表麵結合的增加與(yu) PMNs內(nei) 化的三至四倍增加相關(guan) 。一種寡核苷酸抑製了β2依賴性通過Matrigel的遷移，但粘附在纖維蛋白原上的PMNs的活性氧的產(chan) 生急劇增加。因此，我們(men) 的數據表明，Mac-1是寡脫氧核苷酸的細胞表麵受體(ti) ，可以介導其內(nei) 化，這種結合可能有重要的功能後果。

教授介紹

哥倫(lun) 比亞(ya) 大學

終身教授

1.2008年至2012年期間獲得美國國防部專(zhuan) 項資金。

2.2007年獲得文理職業(ye) 發展Revel獎。

課程大綱-美國和全球公共衛生疾病控製方法及政策研究

COURSE TOPIC: Foundations of Public Health

The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be

adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1: Core Functions of Public Health

• Individual vs population health

• Ten essential services of public health

• Primary, secondary, tertiary prevention

• Introduction to determinants of health

• Social class, racism, discrimination and privilege in public health systems

Session 2: Healthcare Systems and Delivery in the US and Globally

• Approaches to healthcare

• Quality and coverage

• Implementation (e.g., cost, workforce)

• Regulatory systems

• Novel approaches to bridge healthcare and communities

• Social class, racism, discrimination and privilege in healthcare delivery

Session 3: Population Health: Past, Present and Future

• Trends in morbidity and mortality

• History of public health and impact of globalization

• Pragmatic challenges

• Diversity, equity, and inclusion

Session 4:Final

• Public health case:Take COVID-19 as an example

• Final project reveal

課程大綱-免疫係統原理機製及疾病抗體(ti) 研究

COURSE TOPIC: Immunology and Vaccination

The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.

This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1 Introduction to immunology

Acquired immunity- characteristics

Antigen, Haptens and Adjuvants, Antibody

Types of immunity: nonspecificphysiological and cellular barriers

Session 2 Cells and Organs of Immune system

Organs of immune system – primary and secondary

Cells of immunsystem

Humoral Immuneresponse

Session 3 Immuno-techniques