一對一理科課題：研究成年小鼠星形膠質細胞在體外和原位降解澱粉樣蛋白-β

課題內(nei) 容

阿爾茨海默病（AD）是一種進行性神經退行性疾病，其特點是澱粉樣β（Aβ）肽在大腦中過度沉積。AD最早的神經病理變化之一是星形膠質細胞在Aβ沉積部位的堆積1，但這種細胞反應的原因或意義(yi) 尚不清楚。這裏我們(men) 顯示，培養(yang) 的成年小鼠星形膠質細胞在單核細胞誘導蛋白-1（MCP-1）的作用下遷移，這是一種存在於(yu) AD病變中的趨化因子1，並在與(yu) 固定的Aβ1-42相互作用時停止遷移。

我們(men) 還表明，星形膠質細胞會(hui) 結合並降解Aβ1-42。星形膠質細胞鍍在來自AD小鼠模型的充滿Aβ的大腦切片上，與(yu) Aβ沉積物結合，並降低這些切片中的整體(ti) Aβ水平。我們(men) 的結果表明，星形細胞在Aβ沉積物周圍聚集的新機製，表明星形細胞在降解Aβ方麵的直接作用，並將星形膠質細胞清除Aβ的缺陷與(yu) AD的發病機製聯係起來。因此，增加星形細胞清除Aβ的治療可能是減少與(yu) AD相關(guan) 的神經變性的一個(ge) 關(guan) 鍵機製

教授介紹

哥倫(lun) 比亞(ya) 大學

終身教授

1.2008年至2012年期間獲得美國國防部專(zhuan) 項資金。

2.2007年獲得文理職業(ye) 發展Revel獎。

課程大綱-美國和全球公共衛生疾病控製方法及政策研究

COURSE TOPIC: Foundations of Public Health

The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be

adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1: Core Functions of Public Health

• Individual vs population health

• Ten essential services of public health

• Primary, secondary, tertiary prevention

• Introduction to determinants of health

• Social class, racism, discrimination and privilege in public health systems

Session 2: Healthcare Systems and Delivery in the US and Globally

• Approaches to healthcare

• Quality and coverage

• Implementation (e.g., cost, workforce)

• Regulatory systems

• Novel approaches to bridge healthcare and communities

• Social class, racism, discrimination and privilege in healthcare delivery

Session 3: Population Health: Past, Present and Future

• Trends in morbidity and mortality

• History of public health and impact of globalization

• Pragmatic challenges

• Diversity, equity, and inclusion

Session 4:Final

• Public health case:Take COVID-19 as an example

• Final project reveal

課程大綱-免疫係統原理機製及疾病抗體(ti) 研究

COURSE TOPIC: Immunology and Vaccination

The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.

This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1 Introduction to immunology

Acquired immunity- characteristics

Antigen, Haptens and Adjuvants, Antibody

Types of immunity: nonspecificphysiological and cellular barriers

Session 2 Cells and Organs of Immune system

Organs of immune system – primary and secondary

Cells of immunsystem

Humoral Immuneresponse

Session 3 Immuno-techniques