一對一理科課題：探究清道夫受體介導的小膠質細胞與β-澱粉樣蛋白纖維的粘連

課題內(nei) 容

阿爾茨海默病的病理標誌是老年斑，其中包含β-澱粉樣蛋白纖維、小膠質細胞和星形細胞1。β-澱粉樣蛋白纖維對神經元產(chan) 生細胞毒性作用2，並刺激小膠質細胞產(chan) 生神經毒素，如活性氧3,4。單核吞噬細胞，包括小膠質細胞，表達清道夫受體(ti) ，介導氧化的低密度脂蛋白的內(nei) 吞作用5，並粘附於(yu) 葡萄糖修飾的細胞外基質蛋白6。在這裏，我們(men) 報告A類清道夫受體(ti) 介導齧齒動物小膠質細胞和人類單核細胞粘附到β-澱粉樣蛋白纖維包裹的表麵，導致分泌活性氧和細胞固定化。因此，A類清道夫受體(ti) 是阿爾茨海默病的潛在治療目標。

教授介紹

哥倫(lun) 比亞(ya) 大學

終身教授

1.2008年至2012年期間獲得美國國防部專(zhuan) 項資金。

2.2007年獲得文理職業(ye) 發展Revel獎。

課程大綱-美國和全球公共衛生疾病控製方法及政策研究

COURSE TOPIC: Foundations of Public Health

The Professor would like to tailorthe topic to the level ofthe students, so the syllabus can be

adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

This interdisciplinary core course examines public health and healthcare in the US and globally using a social justice lens and emphasizing the interconnectedness of population and individual health. Using public health and healthcare delivery as the overarching framework, the course will cover foundational elements of public health, including, but not limited to, its history and impact, the importance of health equity and human rights, and how racism manifests and is perpetuated within public health and healthcare systems. The course will build a sense of community and instill a public health mindset among students learning and it will lay the foundation for students to work effectively as public health professionals on inter-professional teams.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1: Core Functions of Public Health

• Individual vs population health

• Ten essential services of public health

• Primary, secondary, tertiary prevention

• Introduction to determinants of health

• Social class, racism, discrimination and privilege in public health systems

Session 2: Healthcare Systems and Delivery in the US and Globally

• Approaches to healthcare

• Quality and coverage

• Implementation (e.g., cost, workforce)

• Regulatory systems

• Novel approaches to bridge healthcare and communities

• Social class, racism, discrimination and privilege in healthcare delivery

Session 3: Population Health: Past, Present and Future

• Trends in morbidity and mortality

• History of public health and impact of globalization

• Pragmatic challenges

• Diversity, equity, and inclusion

Session 4:Final

• Public health case:Take COVID-19 as an example

• Final project reveal

課程大綱-免疫係統原理機製及疾病抗體(ti) 研究

COURSE TOPIC: Immunology and Vaccination

The Professor would like to tailor the topic to the level of the students, so the syllabus can be adjusted as needed. These details are subject to change at the professor’s discretion.

Course Description:

Immunology is a highly dynamic field that impacts topical and emerging issues within both the biomedical and biological science disciplines.

This course will see you learn about the components, principles and mechanisms of a healthy immune system, and how they co-ordinate to mount safe and appropriate protection against infection. You will establish how the immune system can distinguish between self and non-self targets, how it can tune responses to protect against different types of infectious agents and how responses vary when these agents are encountered in different anatomical sites, such as in the skin, gut and lung.

Structure:

This course is broken up into four sessions, each spanning one week.

Schedule:

Session 1 Introduction to immunology

Acquired immunity- characteristics

Antigen, Haptens and Adjuvants, Antibody

Types of immunity: nonspecificphysiological and cellular barriers

Session 2 Cells and Organs of Immune system

Organs of immune system – primary and secondary

Cells of immunsystem

Humoral Immuneresponse

Session 3 Immuno-techniques